Reaction Details |
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Target | Cyclin-dependent kinase 1 |
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Ligand | BDBM50212031 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_444510 (CHEMBL894747) |
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IC50 | 2100±n/a nM |
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Citation | Hughes, TV; Emanuel, SL; Beck, AK; Wetter, SK; Connolly, PJ; Karnachi, P; Reuman, M; Seraj, J; Fuentes-Pesquera, AR; Gruninger, RH; Middleton, SA; Lin, R; Davis, JM; Moffat, DF 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett17:3266-70 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 1 |
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Name: | Cyclin-dependent kinase 1 |
Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 34101.08 |
Organism: | Homo sapiens (Human) |
Description: | P06493 |
Residue: | 297 |
Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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BDBM50212031 |
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n/a |
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Name | BDBM50212031 |
Synonyms: | 2-(4-(3-morpholino-3-oxopropyl)phenylamino)-4-phenylpyrimidine-5-carbonitrile | CHEMBL233456 |
Type | Small organic molecule |
Emp. Form. | C24H23N5O2 |
Mol. Mass. | 413.4717 |
SMILES | O=C(CCc1ccc(Nc2ncc(C#N)c(n2)-c2ccccc2)cc1)N1CCOCC1 |
Structure |
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