Reaction Details |
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Target | Cathepsin S |
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Ligand | BDBM50223929 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_458258 (CHEMBL924504) |
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IC50 | >1000±n/a nM |
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Citation | Teno, N; Miyake, T; Ehara, T; Irie, O; Sakaki, J; Ohmori, O; Gunji, H; Matsuura, N; Masuya, K; Hitomi, Y; Nonomura, K; Horiuchi, M; Gohda, K; Iwasaki, A; Umemura, I; Tada, S; Kometani, M; Iwasaki, G; Cowan-Jacob, SW; Missbach, M; Lattmann, R; Betschart, C Novel scaffold for cathepsin K inhibitors. Bioorg Med Chem Lett17:6096-100 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin S |
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Name: | Cathepsin S |
Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
Type: | Protein |
Mol. Mass.: | 37507.38 |
Organism: | Homo sapiens (Human) |
Description: | P25774 |
Residue: | 331 |
Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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BDBM50223929 |
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n/a |
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Name | BDBM50223929 |
Synonyms: | 7-(2,2-Dimethyl-propyl)-6-(3-methyl-2,4-dioxo-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-7Hpyrrolo[2,3-d]pyrimidine-2-carbonitrile | 7-(2,2-dimethyl-propyl)-6-(3-methyl-2,4-dioxo-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | CHEMBL249965 |
Type | Small organic molecule |
Emp. Form. | C21H27N7O2 |
Mol. Mass. | 409.4848 |
SMILES | CN1C(=O)NC2(CCN(Cc3cc4cnc(nc4n3CC(C)(C)C)C#N)CC2)C1=O |
Structure |
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