| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50243676 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491618 (CHEMBL945389) |
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| Ki | 4±n/a nM |
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| Citation |  Santora, VJ; Covel, JA; Hayashi, R; Hofilena, BJ; Ibarra, JB; Pulley, MD; Weinhouse, MI; Semple, G; Ren, A; Pereira, G; Edwards, JE; Suarez, M; Frazer, J; Thomsen, W; Hauser, E; Lorea, J; Grottick, AJ Novel H3 receptor antagonists with improved pharmacokinetic profiles. Bioorg Med Chem Lett18:4133-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50243676 |
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| n/a |
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| Name | BDBM50243676 |
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| Synonyms: | ((3aR,6aR)-6-(4-(2-(pyrrolidin-1-yl)ethyl)phenyl)-1,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl)(tetrahydrofuran-3-yl)methanone | CHEMBL511657 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N2O2 |
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| Mol. Mass. | 380.5231 |
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| SMILES | O=C(C1CCOC1)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:12| |
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| Structure | 
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