| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM50242917 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_491618 (CHEMBL945389) |
|---|
| Ki | 12±n/a nM |
|---|
| Citation |  Santora, VJ; Covel, JA; Hayashi, R; Hofilena, BJ; Ibarra, JB; Pulley, MD; Weinhouse, MI; Semple, G; Ren, A; Pereira, G; Edwards, JE; Suarez, M; Frazer, J; Thomsen, W; Hauser, E; Lorea, J; Grottick, AJ Novel H3 receptor antagonists with improved pharmacokinetic profiles. Bioorg Med Chem Lett18:4133-6 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48607.98 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
|
|
|
|---|
| BDBM50242917 |
|---|
| n/a |
|---|
| Name | BDBM50242917 |
|---|
| Synonyms: | (3aR,6aR)-2-(isopropylsulfonyl)-6-(4-(2-(pyrrolidin-1-yl)ethyl)phenyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrole | CHEMBL472505 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H32N2O2S |
|---|
| Mol. Mass. | 388.567 |
|---|
| SMILES | CC(C)S(=O)(=O)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:10| |
|---|
| Structure | 
|
|---|
Search and Browse
