| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50251831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_488153 (CHEMBL990114) |
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| EC50 | 2300±n/a nM |
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| Citation |  Bertram, LS; Black, D; Briner, PH; Chatfield, R; Cooke, A; Fyfe, MC; Murray, PJ; Naud, F; Nawano, M; Procter, MJ; Rakipovski, G; Rasamison, CM; Reynet, C; Schofield, KL; Shah, VK; Spindler, F; Taylor, A; Turton, R; Williams, GM; Wong-Kai-In, P; Yasuda, K SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1. J Med Chem51:4340-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50251831 |
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| n/a |
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| Name | BDBM50251831 |
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| Synonyms: | 2-(4-(methylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)-N-(thiazol-2-yl)acrylamide | CHEMBL481166 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N2O4S2 |
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| Mol. Mass. | 392.492 |
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| SMILES | CS(=O)(=O)c1ccc(cc1)C(=C/C1CCOCC1)\C(=O)Nc1nccs1 |
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| Structure | 
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