Reaction Details |
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Target | Squalene synthase |
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Ligand | BDBM50287114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_202100 |
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IC50 | 2400±n/a nM |
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Citation | Lamothe, M; Perrin, D; Blotières, D; Leborgne, M; Gras, S; Bonnet, D; Hill, BT; Halazy, S Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine Bioorg Med Chem Lett6:1291-1296 (1996) Article |
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More Info.: | Get all data from this article, Assay Method |
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Squalene synthase |
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Name: | Squalene synthase |
Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
Type: | PROTEIN |
Mol. Mass.: | 48109.41 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1336736 |
Residue: | 416 |
Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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BDBM50287114 |
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n/a |
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Name | BDBM50287114 |
Synonyms: | (4E,8E)-2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid | CHEMBL24377 |
Type | Small organic molecule |
Emp. Form. | C27H37NO5 |
Mol. Mass. | 455.5864 |
SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6](-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6](-[#6]-c1ccccc1)-[#6](-[#8])=O |
Structure |
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