| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50290390 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_41418 (CHEMBL654399) |
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| IC50 | 920±n/a nM |
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| Citation |  Martin, LL; Davis, L; Klein, JT; Nemoto, P; Olsen, GE; Bores, GM; Camacho, F; Petko, WW; Rush, DK; Selk, D; Smith, CP; Vargas, HM; Winslow, JT; Effland, RC; Fink, DM Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitor Bioorg Med Chem Lett7:157-162 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
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| Type: | Homotetramer |
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| Mol. Mass.: | 68422.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06276 |
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| Residue: | 602 |
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| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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| BDBM50290390 |
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| n/a |
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| Name | BDBM50290390 |
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| Synonyms: | Butyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-propyl-amino]-3-methyl-1H-indol-5-yl ester | CHEMBL290628 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27FN4O2 |
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| Mol. Mass. | 398.4738 |
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| SMILES | CCCCNC(=O)Oc1ccc2n(cc(C)c2c1)N(CCC)c1ccncc1F |
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| Structure | 
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