| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 3 |
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| Ligand | BDBM50225353 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_581435 (CHEMBL1055679) |
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| IC50 | 640±n/a nM |
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| Citation |  Sato, I; Morihira, K; Inami, H; Kubota, H; Morokata, T; Suzuki, K; Ohno, K; Iura, Y; Nitta, A; Imaoka, T; Takahashi, T; Takeuchi, M; Ohta, M; Tsukamoto, S Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists. Bioorg Med Chem17:5989-6002 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 3 |
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| Name: | C-C chemokine receptor type 3 |
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| Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 41053.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51677 |
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| Residue: | 355 |
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| Sequence: | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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| BDBM50225353 |
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| n/a |
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| Name | BDBM50225353 |
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| Synonyms: | 4-fluoro-N-(1-((6-fluoronaphthalen-2-yl)methyl)piperidin-4-yl)benzamide | 4-fluoro-N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide | CHEMBL408407 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22F2N2O |
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| Mol. Mass. | 380.4304 |
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| SMILES | Fc1ccc(cc1)C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 |
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| Structure | 
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