Reaction Details |
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Target | Renin |
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Ligand | BDBM50311797 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_619907 (CHEMBL1110297) |
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IC50 | 4000±n/a nM |
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Citation | Remen, L; Bezençon, O; Richard-Bildstein, S; Bur, D; Prade, L; Corminboeuf, O; Boss, C; Grisostomi, C; Sifferlen, T; Strickner, P; Hess, P; Delahaye, S; Treiber, A; Weller, T; Binkert, C; Steiner, B; Fischli, W New classes of potent and bioavailable human renin inhibitors. Bioorg Med Chem Lett19:6762-5 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50311797 |
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n/a |
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Name | BDBM50311797 |
Synonyms: | 8-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)phenyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-5-azaspiro[2.5]oct-7-ene-7-carboxamide | CHEMBL1076450 |
Type | Small organic molecule |
Emp. Form. | C33H31Cl3F2N2O2 |
Mol. Mass. | 631.967 |
SMILES | Fc1ccc(F)c(OCCCc2ccc(cc2)C2=C(CNCC22CC2)C(=O)N(Cc2cccc(Cl)c2Cl)C2CC2)c1Cl |t:18| |
Structure |
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