| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF11 |
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| Ligand | BDBM50321240 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_638385 (CHEMBL1167212) |
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| IC50 | 76±n/a nM |
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| Citation |  Liu, F; Yu, LQ; Jiang, C; Yang, L; Wu, WT; You, QD Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. Bioorg Med Chem18:4167-77 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF11 |
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| Name: | Kinesin-like protein KIF11 |
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| Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 119138.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1457426 |
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| Residue: | 1056 |
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| Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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| BDBM50321240 |
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| n/a |
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| Name | BDBM50321240 |
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| Synonyms: | (+/-)-1-(3-Hydroxyphenyl)-2-(p-aminobenzoyl)-6-chloro-1,2,3,4-tetrahydro-beta-carboline | CHEMBL1164476 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20ClN3O2 |
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| Mol. Mass. | 417.888 |
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| SMILES | Nc1ccc(cc1)C(=O)N1CCc2c([nH]c3ccc(Cl)cc23)C1c1cccc(O)c1 |
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| Structure | 
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