| Reaction Details |
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 | Report a problem with these data |
| Target | Aminopeptidase N |
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| Ligand | BDBM50323957 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_647222 (CHEMBL1217363) |
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| IC50 | 304210±n/a nM |
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| Citation |  Zhang, X; Fang, H; Zhu, H; Wang, X; Zhang, L; Li, M; Li, Q; Yuan, Y; Xu, W Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione. Bioorg Med Chem18:5981-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aminopeptidase N |
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| Name: | Aminopeptidase N |
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| Synonyms: | AMPN_PIG | ANPEP | AP-M | AP-N | Alanyl aminopeptidase | Aminopeptidase M | Aminopeptidase N (APN) | CD_antigen=CD13 | Microsomal aminopeptidase | gp130 | pAPN |
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| Type: | Protein |
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| Mol. Mass.: | 108810.25 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | P15145 |
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| Residue: | 963 |
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| Sequence: | MAKGFYISKALGILGILLGVAAVATIIALSVVYAQEKNKNAEHVPQAPTSPTITTTAAIT
LDQSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRLLCQEPTDVIIIHS
KKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGE
LADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTA
LSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWAR
PNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYREN
ALLFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHA
EPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISEMFDSISYSKGASVIR
MLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWT
LQMGFPVITVDTKTGNISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRD
VSQAQNDLFKTASDDWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIY
DSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLR
KQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDP
ENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNR
YLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQ
GVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFI
EHS
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| BDBM50323957 |
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| n/a |
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| Name | BDBM50323957 |
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| Synonyms: | (2S)-2-Amino-N-(1-(2-(2-(hydroxyamino)-2-oxoethylamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide | CHEMBL1213798 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N5O6 |
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| Mol. Mass. | 405.4051 |
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| SMILES | N[C@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)N(CC(=O)NCC(=O)NO)C1=O |r| |
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| Structure | 
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