Reaction Details |
| Report a problem with these data |
Target | Malonyl-CoA decarboxylase, mitochondrial |
---|
Ligand | BDBM50328231 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_665404 (CHEMBL1261133) |
---|
IC50 | 14±n/a nM |
---|
Citation | Tang, H; Yan, Y; Feng, Z; de Jesus, RK; Yang, L; Levorse, DA; Owens, KA; Akiyama, TE; Bergeron, R; Castriota, GA; Doebber, TW; Ellsworth, KP; Lassman, ME; Li, C; Wu, MS; Zhang, BB; Chapman, KT; Mills, SG; Berger, JP; Pasternak, A Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett20:6088-92 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Malonyl-CoA decarboxylase, mitochondrial |
---|
Name: | Malonyl-CoA decarboxylase, mitochondrial |
Synonyms: | DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase |
Type: | PROTEIN |
Mol. Mass.: | 55018.37 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_665404 |
Residue: | 493 |
Sequence: | MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKT
PAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAA
VLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNG
VLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFF
SHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQG
VELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSEC
KEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVA
NFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQV
LSLVAQFQKNSKL
|
|
|
BDBM50328231 |
---|
n/a |
---|
Name | BDBM50328231 |
Synonyms: | 3-(4-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiazol-2-yl)piperidin-1-yl)benzamide | CHEMBL1257319 |
Type | Small organic molecule |
Emp. Form. | C18H17F6N3O2S |
Mol. Mass. | 453.402 |
SMILES | NC(=O)c1cccc(c1)N1CCC(CC1)c1ncc(s1)C(O)(C(F)(F)F)C(F)(F)F |
Structure |
|