| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
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| Ligand | BDBM50328525 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_665682 (CHEMBL1261613) |
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| IC50 | 98±n/a nM |
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| Citation |  Zhou, C; Garcia-Calvo, M; Pinto, S; Lombardo, M; Feng, Z; Bender, K; Pryor, KD; Bhatt, UR; Chabin, RM; Geissler, WM; Shen, Z; Tong, X; Zhang, Z; Wong, KK; Roy, RS; Chapman, KT; Yang, L; Xiong, Y Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity. J Med Chem53:7251-63 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal Pro-X carboxypeptidase |
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| Name: | Lysosomal Pro-X carboxypeptidase |
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| Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55028.96 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1335505 |
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| Residue: | 491 |
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| Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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| BDBM50328525 |
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| n/a |
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| Name | BDBM50328525 |
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| Synonyms: | CHEMBL1259221 | N-{(2S,3S)-1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)-pyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-yl}-2-hydroxy-2-methylpropanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28Cl2N4O3 |
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| Mol. Mass. | 503.421 |
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| SMILES | C[C@H]([C@H](NC(=O)C(C)(C)O)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| |
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| Structure | 
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