| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
|---|
| Ligand | BDBM50328557 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_665678 (CHEMBL1261609) |
|---|
| IC50 | 56±n/a nM |
|---|
| Citation |  Zhou, C; Garcia-Calvo, M; Pinto, S; Lombardo, M; Feng, Z; Bender, K; Pryor, KD; Bhatt, UR; Chabin, RM; Geissler, WM; Shen, Z; Tong, X; Zhang, Z; Wong, KK; Roy, RS; Chapman, KT; Yang, L; Xiong, Y Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity. J Med Chem53:7251-63 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal Pro-X carboxypeptidase |
|---|
| Name: | Lysosomal Pro-X carboxypeptidase |
|---|
| Synonyms: | Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55805.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42785 |
|---|
| Residue: | 496 |
|---|
| Sequence: | MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF
GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA
EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY
GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS
WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP
LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS
YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT
NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH
MKNWIRDFYDSAGKQH
|
|
|
|---|
| BDBM50328557 |
|---|
| n/a |
|---|
| Name | BDBM50328557 |
|---|
| Synonyms: | 3-(4'-Methylbiphenyl-4-yl)-1-[(2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl]propan-1-one | CHEMBL1259027 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H29N3O |
|---|
| Mol. Mass. | 435.5601 |
|---|
| SMILES | Cc1ccc(cc1)-c1ccc(CCC(=O)N2CCC[C@H]2c2nc(c[nH]2)-c2ccccc2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
