Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50334869 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_699552 (CHEMBL1647910) |
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IC50 | 17±n/a nM |
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Citation | Labroli, M; Paruch, K; Dwyer, MP; Alvarez, C; Keertikar, K; Poker, C; Rossman, R; Duca, JS; Fischmann, TO; Madison, V; Parry, D; Davis, N; Seghezzi, W; Wiswell, D; Guzi, TJ Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2. Bioorg Med Chem Lett21:471-4 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50334869 |
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n/a |
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Name | BDBM50334869 |
Synonyms: | 6-bromo-5-(piperidin-3-yl)-3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine | CHEMBL1643223 |
Type | Small organic molecule |
Emp. Form. | C16H17BrN6 |
Mol. Mass. | 373.25 |
SMILES | Nc1c(Br)c(nc2c(cnn12)-c1cccnc1)C1CCCNC1 |
Structure |
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