Reaction Details | |||
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Target | Bifunctional epoxide hydrolase 2 | ||
Ligand | BDBM50335975 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_716996 (CHEMBL1671068) | ||
IC50 | 25±n/a nM | ||
Citation | Anandan, SK; Webb, HK; Chen, D; Wang, YX; Aavula, BR; Cases, S; Cheng, Y; Do, ZN; Mehra, U; Tran, V; Vincelette, J; Waszczuk, J; White, K; Wong, KR; Zhang, LN; Jones, PD; Hammock, BD; Patel, DV; Whitcomb, R; MacIntyre, DE; Sabry, J; Gless, R 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. Bioorg Med Chem Lett21:983-8 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Bifunctional epoxide hydrolase 2 | |||
Name: | Bifunctional epoxide hydrolase 2 | ||
Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
Type: | Enzyme | ||
Mol. Mass.: | 62613.07 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34913 | ||
Residue: | 555 | ||
Sequence: |
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BDBM50335975 | |||
n/a | |||
Name | BDBM50335975 | ||
Synonyms: | 1-(1-Acetyl-piperidin-4-yl)-3-(4-methyl-bicyclo[2.2.2]oct-2-yl)-urea | CHEMBL1668925 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H29N3O2 | ||
Mol. Mass. | 307.4311 | ||
SMILES | CC(=O)N1CCC(CC1)NC(=O)NC1CC2(C)CCC1CC2 |(19.45,7.01,;19.4,5.47,;18.03,4.74,;20.7,4.65,;22.06,5.37,;23.37,4.56,;23.3,3.02,;21.96,2.29,;20.65,3.11,;24.61,2.21,;24.57,.67,;23.21,-.06,;25.88,-.14,;25.86,-1.68,;26.33,-2.77,;26.12,-4.67,;26.14,-6.19,;27.5,-5.27,;27.19,-3.88,;25.83,-3.31,;24.39,-3.99,;24.61,-5.36,)| | ||
Structure |