Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Histamine H1 receptor |
---|
Ligand | BDBM50336066 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_718096 (CHEMBL1671549) |
---|
Ki | 7.2±n/a nM |
---|
Citation | Huang, C; Moree, WJ; Zamani-Kord, S; Li, BF; Tucci, FC; Malany, S; Wen, J; Wang, H; Hoare, SR; Yang, C; Madan, A; Crowe, PD; Beaton, G Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6. Bioorg Med Chem Lett21:947-51 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histamine H1 receptor |
---|
Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
|
|
|
BDBM50336066 |
---|
n/a |
---|
Name | BDBM50336066 |
Synonyms: | CHEMBL1669405 | N-ethyl-N-methyl-2-(3-(pyrazin-2-ylmethyl)-1H-inden-2-yl)ethanamine |
Type | Small organic molecule |
Emp. Form. | C19H23N3 |
Mol. Mass. | 293.406 |
SMILES | CCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 |c:6| |
Structure |
|