| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50336074 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_718096 (CHEMBL1671549) |
|---|
| Ki | 2.8±n/a nM |
|---|
| Citation |  Huang, C; Moree, WJ; Zamani-Kord, S; Li, BF; Tucci, FC; Malany, S; Wen, J; Wang, H; Hoare, SR; Yang, C; Madan, A; Crowe, PD; Beaton, G Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6. Bioorg Med Chem Lett21:947-51 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 55808.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
|---|
| Residue: | 487 |
|---|
| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
|
|
|
|---|
| BDBM50336074 |
|---|
| n/a |
|---|
| Name | BDBM50336074 |
|---|
| Synonyms: | 2-((2-(2-(pyrrolidin-1-yl)ethyl)-1H-inden-3-yl)methyl)pyrazine | CHEMBL1669413 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H23N3 |
|---|
| Mol. Mass. | 305.4167 |
|---|
| SMILES | C(CC1=C(Cc2cnccn2)c2ccccc2C1)N1CCCC1 |c:2| |
|---|
| Structure | 
|
|---|
Search and Browse
