| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50336088 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_718096 (CHEMBL1671549) |
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| Ki | 15.2±n/a nM |
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| Citation |  Huang, C; Moree, WJ; Zamani-Kord, S; Li, BF; Tucci, FC; Malany, S; Wen, J; Wang, H; Hoare, SR; Yang, C; Madan, A; Crowe, PD; Beaton, G Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6. Bioorg Med Chem Lett21:947-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM50336088 |
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| n/a |
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| Name | BDBM50336088 |
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| Synonyms: | (R)-N-methyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden-2-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)ethanamine | CHEMBL1669427 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N3O |
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| Mol. Mass. | 377.5224 |
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| SMILES | C[C@H](C1=C(CCN(C)CC2CCOCC2)Cc2ccccc12)c1cnccn1 |r,c:2| |
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| Structure | 
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