| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50338126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727742 (CHEMBL1686101) |
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| IC50 | 251±n/a nM |
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| Citation |  Trujillo, JI; Huang, W; Hughes, RO; Rogier, DJ; Turner, SR; Devraj, R; Morton, PA; Xue, CB; Chao, G; Covington, MB; Newton, RC; Metcalf, B Design and synthesis of novel CCR2 antagonists: investigation of non-aryl/heteroaryl binding motifs. Bioorg Med Chem Lett21:1827-31 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50338126 |
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| n/a |
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| Name | BDBM50338126 |
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| Synonyms: | CHEMBL1684682 | tert-butyl 4-((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)cyclopentanecarbonyl)piperazine-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C23H43N3O4 |
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| Mol. Mass. | 425.6052 |
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| SMILES | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](C1)(C(C)C)N1CCN(CC1)C(=O)OC(C)(C)C |r| |
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| Structure | 
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