| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-2 adrenergic receptor |
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| Ligand | BDBM50338815 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727081 (CHEMBL1687005) |
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| IC50 | 2180±n/a nM |
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| Citation |  Morriello, GJ; Wendt, HR; Bansal, A; Di Salvo, J; Feighner, S; He, J; Hurley, AL; Hreniuk, DL; Salituro, GM; Reddy, MV; Galloway, SM; McGettigan, KK; Laws, G; McKnight, C; Doss, GA; Tsou, NN; Black, RM; Morris, J; Ball, RG; Sanfiz, AT; Streckfuss, E; Struthers, M; Edmondson, SD Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective humanß3 adrenergic receptor agonists. Bioorg Med Chem Lett21:1865-70 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-2 adrenergic receptor |
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| Name: | Beta-2 adrenergic receptor |
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| Synonyms: | ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor |
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| Type: | n/a |
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| Mol. Mass.: | 46461.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07550 |
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| Residue: | 413 |
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| Sequence: | MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
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| BDBM50338815 |
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| n/a |
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| Name | BDBM50338815 |
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| Synonyms: | CHEMBL1684577 | N-(4-(((5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C34H30F3N3O3S2 |
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| Mol. Mass. | 649.746 |
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| SMILES | O[C@@H]([C@H]1CCC(Cc2ccc(NS(=O)(=O)c3ccc(cc3)-c3nc(cs3)-c3ccc(cc3)C(F)(F)F)cc2)N1)c1ccccc1 |r| |
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| Structure | 
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