| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
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| Ligand | BDBM50338816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727078 (CHEMBL1687002) |
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| EC50 | 2030±n/a nM |
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| Citation |  Morriello, GJ; Wendt, HR; Bansal, A; Di Salvo, J; Feighner, S; He, J; Hurley, AL; Hreniuk, DL; Salituro, GM; Reddy, MV; Galloway, SM; McGettigan, KK; Laws, G; McKnight, C; Doss, GA; Tsou, NN; Black, RM; Morris, J; Ball, RG; Sanfiz, AT; Streckfuss, E; Struthers, M; Edmondson, SD Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective humanß3 adrenergic receptor agonists. Bioorg Med Chem Lett21:1865-70 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-3 adrenergic receptor |
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| Name: | Beta-3 adrenergic receptor |
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| Synonyms: | ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 43534.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 408 |
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| Sequence: | MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
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| BDBM50338816 |
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| n/a |
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| Name | BDBM50338816 |
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| Synonyms: | CHEMBL1684580 | N-(4-(((5S)-5-((S)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C34H30F3N3O3S2 |
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| Mol. Mass. | 649.746 |
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| SMILES | O[C@H]([C@@H]1CCC(Cc2ccc(NS(=O)(=O)c3ccc(cc3)-c3nc(cs3)-c3ccc(cc3)C(F)(F)F)cc2)N1)c1ccccc1 |r| |
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| Structure | 
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