Reaction Details |
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Target | Beta-1 adrenergic receptor |
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Ligand | BDBM50338814 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_727080 (CHEMBL1687004) |
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IC50 | 1040±n/a nM |
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Citation | Morriello, GJ; Wendt, HR; Bansal, A; Di Salvo, J; Feighner, S; He, J; Hurley, AL; Hreniuk, DL; Salituro, GM; Reddy, MV; Galloway, SM; McGettigan, KK; Laws, G; McKnight, C; Doss, GA; Tsou, NN; Black, RM; Morris, J; Ball, RG; Sanfiz, AT; Streckfuss, E; Struthers, M; Edmondson, SD Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective humanß3 adrenergic receptor agonists. Bioorg Med Chem Lett21:1865-70 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-1 adrenergic receptor |
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Name: | Beta-1 adrenergic receptor |
Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 51338.40 |
Organism: | Homo sapiens (Human) |
Description: | P08588 |
Residue: | 477 |
Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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BDBM50338814 |
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n/a |
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Name | BDBM50338814 |
Synonyms: | (R)-N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide | CHEMBL1684578 |
Type | Small organic molecule |
Emp. Form. | C32H28F3N3O3S2 |
Mol. Mass. | 623.708 |
SMILES | O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(cc2)-c2nc(cs2)-c2ccc(cc2)C(F)(F)F)cc1)c1ccccc1 |r| |
Structure |
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