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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity mitogen-activated protein kinase kinase 1 | ||
| Ligand | BDBM50340954 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_739944 (CHEMBL1763004) | ||
| IC50 | 960±n/a nM | ||
| Citation |  Crew, AP; Bhagwat, SV; Dong, H; Bittner, MA; Chan, A; Chen, X; Coate, H; Cooke, A; Gokhale, PC; Honda, A; Jin, M; Kahler, J; Mantis, C; Mulvihill, MJ; Tavares-Greco, PA; Volk, B; Wang, J; Werner, DS; Arnold, LD; Pachter, JA; Wild, R; Gibson, NW Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2. Bioorg Med Chem Lett21:2092-7 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity mitogen-activated protein kinase kinase 1 | |||
| Name: | Dual specificity mitogen-activated protein kinase kinase 1 | ||
| Synonyms: | Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAP2K1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | MEK1 | MP2K1_HUMAN | Mitogen-activated protein kinase 1 (MEK1) | PRKMK1 | VHL-MAP2K1/MAP2K2 | ||
| Type: | Other Protein Type | ||
| Mol. Mass.: | 43439.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates. | ||
| Residue: | 393 | ||
| Sequence: |
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| BDBM50340954 | |||
| n/a | |||
| Name | BDBM50340954 | ||
| Synonyms: | CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methyl)acetamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H26N6O | ||
| Mol. Mass. | 402.4921 | ||
| SMILES | CC(=O)NC[C@H]1CC[C@@H](CC1)c1nc(-c2cc3ccccc3[nH]2)c2c(N)nccn12 |r,wU:8.11,wD:5.4,(30.4,-52.78,;31.44,-51.63,;32.94,-51.96,;30.97,-50.17,;32,-49.03,;31.53,-47.56,;32.56,-46.41,;32.09,-44.94,;30.58,-44.63,;29.54,-45.77,;30.01,-47.24,;30.1,-43.16,;31.01,-41.9,;30.1,-40.65,;30.58,-39.19,;29.67,-37.94,;30.58,-36.7,;30.27,-35.2,;31.41,-34.17,;32.87,-34.65,;33.19,-36.15,;32.04,-37.18,;32.04,-38.72,;28.62,-41.13,;27.29,-40.37,;27.29,-38.83,;25.96,-41.14,;25.96,-42.68,;27.29,-43.45,;28.63,-42.68,)| | ||
| Structure | 
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