Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50314631 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_759500 (CHEMBL1810941) |
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IC50 | 26±n/a nM |
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Citation | Shultz, M; Fan, J; Chen, C; Cho, YS; Davis, N; Bickford, S; Buteau, K; Cao, X; Holmqvist, M; Hsu, M; Jiang, L; Liu, G; Lu, Q; Patel, C; Suresh, JR; Selvaraj, M; Urban, L; Wang, P; Yan-Neale, Y; Whitehead, L; Zhang, H; Zhou, L; Atadja, P The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors. Bioorg Med Chem Lett21:4909-12 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50314631 |
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n/a |
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Name | BDBM50314631 |
Synonyms: | CHEMBL1088949 | N-hydroxy-3-(2-(2-(2-methyl-1H-indol-3-yl)ethyl)isoindolin-5-yl)acrylamide |
Type | Small organic molecule |
Emp. Form. | C22H23N3O2 |
Mol. Mass. | 361.4369 |
SMILES | Cc1[nH]c2ccccc2c1CCN1Cc2ccc(\C=C\C(=O)NO)cc2C1 |
Structure |
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