| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
|---|
| Ligand | BDBM20716 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_771071 (CHEMBL1838732) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Motiwala, H; Kandre, S; Birar, V; Kadam, KS; Rodge, A; Jadhav, RD; Mahesh Kumar Reddy, M; Brahma, MK; Deshmukh, NJ; Dixit, A; Doshi, L; Gupte, A; Gangopadhyay, AK; Vishwakarma, RA; Srinivasan, S; Sharma, M; Nemmani, KV; Sharma, R Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors. Bioorg Med Chem Lett21:5812-7 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol O-acyltransferase 1 |
|---|
| Name: | Diacylglycerol O-acyltransferase 1 |
|---|
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55297.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75907 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
|
|
|
|---|
| BDBM20716 |
|---|
| n/a |
|---|
| Name | BDBM20716 |
|---|
| Synonyms: | (1R,2R)-2-[(4-{4-[(phenylcarbamoyl)amino]phenyl}phenyl)carbonyl]cyclopentane-1-carboxylic acid | Urea-based Analogue, 4a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H24N2O4 |
|---|
| Mol. Mass. | 428.4798 |
|---|
| SMILES | OC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(cc1)-c1ccc(NC(=O)Nc2ccccc2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
