| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50112972 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_221513 |
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| IC50 | 1600±n/a nM |
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| Citation |  Hobbs, CJ; Bit, RA; Cansfield, AD; Harris, B; Hill, CH; Hilyard, KL; Kilford, IR; Kitas, E; Kroehn, A; Lovell, P; Pole, D; Rugman, P; Sherborne, BS; Smith, IE; Vesey, DR; Walmsley, DL; Whittaker, D; Williams, G; Wilson, F; Banner, D; Surgenor, A; Borkakoti, N Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain. Bioorg Med Chem Lett12:1365-9 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50112972 |
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| n/a |
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| Name | BDBM50112972 |
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| Synonyms: | (S)-4-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-carboxy-butyrylamino}-4-[(1S,2S)-2-methyl-1-((R)-2-methylcarbamoyl-pyrrolidine-1-carbonyl)-butylcarbamoyl]-butyric acid | CHEMBL281452 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H49N6O14P |
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| Mol. Mass. | 784.7477 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@@H]1C(=O)NC |
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| Structure | 
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