| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50005169 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63659 |
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| IC50 | 107±n/a nM |
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| Citation |  Skiles, JW; Fuchs, V; Miao, C; Sorcek, R; Grozinger, KG; Mauldin, SC; Vitous, J; Mui, PW; Jacober, S; Chow, G Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones. J Med Chem35:641-62 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50005169 |
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| n/a |
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| Name | BDBM50005169 |
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| Synonyms: | 3-Acetoxymethyl-7-acetyl-5,5-dihydroxy-8-oxo-5lambda*4*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester | CHEMBL3143494 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21NO8S |
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| Mol. Mass. | 387.405 |
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| SMILES | CC(=O)OCC1=C(N2C([C@H](C(C)=O)C2=O)S(=O)(=O)C1)C(=O)OC(C)(C)C |r,t:5| |
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| Structure | 
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