| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50086883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_160747 (CHEMBL769061) |
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| Ki | 12±n/a nM |
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| Citation |  Fairlie, DP; Tyndall, JD; Reid, RC; Wong, AK; Abbenante, G; Scanlon, MJ; March, DR; Bergman, DA; Chai, CL; Burkett, BA Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing. J Med Chem43:1271-81 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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| BDBM50086883 |
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| n/a |
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| Name | BDBM50086883 |
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| Synonyms: | 2-{2-[2-(8-Carbamoylmethyl-6,9-dioxo-2-oxa-7,10-diaza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-trien-11-yl)-2-hydroxy-ethylamino]-3-phenyl-propionylamino}-3-methyl-pentanoic acid (1-carb amoyl-2-methyl-propyl)-amide | CHEMBL281586 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H55N7O8 |
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| Mol. Mass. | 737.8854 |
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| SMILES | CCC(C)C(NC(=O)C(Cc1ccccc1)NC[C@H](O)[C@@H]1Cc2ccc(OCCCC(=O)N[C@@H](CC(N)=O)C(=O)N1)cc2)C(=O)NC(C(C)C)C(N)=O |
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| Structure | 
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