Ki Summary

Reaction Details

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Target

Sphingosine 1-phosphate receptor 5

Ligand

BDBM50152337

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_306057 (CHEMBL833013)

IC50

0.77±n/a nM

Citation

Yan, L; Hale, JJ; Lynch, CL; Budhu, R; Gentry, A; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Rosen, H; Mandala, SM Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors. Bioorg Med Chem Lett14:4861-6 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-phosphate receptor 5

Name:

Sphingosine 1-phosphate receptor 5

Synonyms:

EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41796.42

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

398

Sequence:

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

BDBM50152337

n/a

Name

BDBM50152337

Synonyms:

2-amino-2-({[dihydroxy(oxido)--phosphanyl]oxy}methyl)-4-(4-octylphenyl)butan-1-ol | 3-(N-alkylamino) propylphosphonic acid derivative

Type

Small organic molecule

Emp. Form.

C19H35NO5P

Mol. Mass.

388.4592

SMILES

CCCCCCCCc1ccc(CCC(N)(CO)COP(O)(O)[O-])cc1

Structure