| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidine phosphorylase |
|---|
| Ligand | BDBM50159217 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305483 (CHEMBL830274) |
|---|
| IC50 | 6500±n/a nM |
|---|
| Citation |  Reigan, P; Edwards, PN; Gbaj, A; Cole, C; Barry, ST; Page, KM; Ashton, SE; Luke, RW; Douglas, KT; Stratford, IJ; Jaffar, M; Bryce, RA; Freeman, S Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs. J Med Chem48:392-402 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidine phosphorylase |
|---|
| Name: | Thymidine phosphorylase |
|---|
| Synonyms: | TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 47198.54 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | n/a |
|---|
| Residue: | 440 |
|---|
| Sequence: | MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLT
MAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHT
GGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSI
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLT
DMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKL
QAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALG
MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAA
IKLADKAPESTPTVYRRISE
|
|
|
|---|
| BDBM50159217 |
|---|
| n/a |
|---|
| Name | BDBM50159217 |
|---|
| Synonyms: | 4-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylmethyl)-3H-imidazol-1-ium | CHEMBL194765 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H9BrN5O2 |
|---|
| Mol. Mass. | 287.093 |
|---|
| SMILES | Nc1c[n+](Cc2[nH]c(=O)[nH]c(=O)c2Br)c[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
