Reaction Details |
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Target | Prothrombin |
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Ligand | BDBM50235535 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_462712 (CHEMBL929685) |
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IC50 | 23±n/a nM |
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Citation | Hanessian, S; Simard, D; Bayrakdarian, M; Therrien, E; Nilsson, I; Fjellström, O Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs. Bioorg Med Chem Lett18:1972-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prothrombin |
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Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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BDBM50235535 |
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n/a |
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Name | BDBM50235535 |
Synonyms: | CHEMBL559192 | N-(4-carbamimidoyl-benzyl)-2-[4-methyl-2-oxo-1-(2-o-tolyl-ethylamino)-1,2-dihydro-pyridin-3-yl]-acetamide hydrochloride |
Type | Small organic molecule |
Emp. Form. | C25H29N5O2 |
Mol. Mass. | 431.5301 |
SMILES | Cc1ccccc1CCNn1ccc(C)c(CC(=O)NCc2ccc(cc2)C(N)=N)c1=O |
Structure |
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