Citation | Martin, MW; Newcomb, J; Nunes, JJ; Boucher, C; Chai, L; Epstein, LF; Faust, T; Flores, S; Gallant, P; Gore, A; Gu, Y; Hsieh, F; Huang, X; Kim, JL; Middleton, S; Morgenstern, K; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, P; Tudor, Y; Turci, SM; Welcher, AA; Zack, D; Zhao, H; Zhu, L; Zhu, X; Ghiron, C; Ermann, M; Johnston, D; Saluste, CG Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem51:1637-48 (2008) [PubMed] Article |
---|
SMILES | COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc(OC)c1OCCCN1CCN(C)CC1 |(22.25,-6.46,;20.92,-7.23,;20.91,-8.77,;22.24,-9.54,;22.23,-11.08,;23.56,-11.85,;24.9,-11.08,;24.9,-9.54,;26.23,-8.77,;27.57,-9.53,;27.57,-11.08,;26.23,-11.85,;28.9,-11.85,;29.22,-13.35,;28.31,-14.58,;28.93,-15.99,;30.46,-16.16,;31.37,-14.92,;30.75,-13.52,;31.38,-12.12,;30.24,-11.08,;30.24,-9.53,;31.58,-8.77,;31.57,-7.23,;30.24,-6.47,;32.9,-6.46,;34.24,-7.23,;34.24,-8.78,;32.9,-9.54,;32.9,-11.08,;28.9,-8.76,;28.9,-7.22,;20.91,-11.85,;19.58,-11.08,;18.25,-11.86,;18.25,-13.4,;19.58,-9.54,;18.24,-8.77,;16.91,-9.54,;15.58,-8.77,;15.58,-7.23,;16.91,-6.46,;18.24,-7.24,;19.57,-6.47,;19.58,-4.93,;20.92,-4.17,;18.25,-4.16,;16.91,-4.92,)| |