Ki Summary

Reaction Details

Report a problem with these data

Target

Proto-oncogene tyrosine-protein kinase Src

Ligand

BDBM50374623

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_469609 (CHEMBL934188)

IC50

360±n/a nM

Citation

Martin, MW; Newcomb, J; Nunes, JJ; Boucher, C; Chai, L; Epstein, LF; Faust, T; Flores, S; Gallant, P; Gore, A; Gu, Y; Hsieh, F; Huang, X; Kim, JL; Middleton, S; Morgenstern, K; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, P; Tudor, Y; Turci, SM; Welcher, AA; Zack, D; Zhao, H; Zhu, L; Zhu, X; Ghiron, C; Ermann, M; Johnston, D; Saluste, CG Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem51:1637-48 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Proto-oncogene tyrosine-protein kinase Src

Name:

Proto-oncogene tyrosine-protein kinase Src

Synonyms:

Type:

Protein

Mol. Mass.:

59838.60

Organism:

Homo sapiens (Human)

Description:

P12931

Residue:

536

Sequence:

MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

BDBM50374623

n/a

Name

BDBM50374623

Synonyms:

CHEMBL261174

Type

Small organic molecule

Emp. Form.

C31H31N7O2

Mol. Mass.

533.6235

SMILES

CN(C)CCCOc1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc1 |(-10.01,-30.27,;-10.01,-31.81,;-11.34,-32.58,;-8.68,-32.58,;-8.68,-34.12,;-7.35,-34.89,;-7.35,-36.43,;-6.01,-37.2,;-4.68,-36.43,;-3.34,-37.2,;-3.36,-38.74,;-2.02,-39.51,;-.69,-38.74,;-.69,-37.2,;.64,-36.43,;1.98,-37.19,;1.98,-38.74,;.64,-39.52,;3.31,-39.51,;3.63,-41.01,;2.73,-42.24,;3.34,-43.65,;4.87,-43.82,;5.78,-42.58,;5.16,-41.18,;5.79,-39.78,;4.65,-38.74,;4.65,-37.19,;5.99,-36.43,;5.98,-34.89,;4.65,-34.13,;7.31,-34.12,;8.65,-34.89,;8.65,-36.44,;7.31,-37.2,;7.31,-38.74,;3.31,-36.42,;3.31,-34.88,;-4.68,-39.51,;-6.01,-38.74,)|

Structure