| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50271771 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_556764 (CHEMBL961462) |
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| IC50 | 4923±n/a nM |
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| Citation |  Martínez-Mayorga, K; Medina-Franco, JL; Giulianotti, MA; Pinilla, C; Dooley, CT; Appel, JR; Houghten, RA Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis. Bioorg Med Chem16:5932-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50271771 |
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| n/a |
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| Name | BDBM50271771 |
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| Synonyms: | (3S,6S)-7-(2-Adamantan-1-yl-ethyl)-3-cyclohexyl-6-(4-methoxy-benzyl)-2,5,6,7-tetrahydro-3H-imidazo[1,2-a]imidazol-1-ium |
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| Type | Small organic molecule |
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| Emp. Form. | C31H46N3O |
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| Mol. Mass. | 476.7159 |
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| SMILES | COc1ccc(C[C@H]2CN3[C@H](C[NH+]=C3N2CCC23CC4CC(CC(C4)C2)C3)C2CCCCC2)cc1 |r,c:12,TLB:16:17:20.19.24:22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17| |
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| Structure | 
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