| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50271454 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_556764 (CHEMBL961462) |
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| IC50 | 1941±n/a nM |
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| Citation |  Martínez-Mayorga, K; Medina-Franco, JL; Giulianotti, MA; Pinilla, C; Dooley, CT; Appel, JR; Houghten, RA Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis. Bioorg Med Chem16:5932-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50271454 |
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| n/a |
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| Name | BDBM50271454 |
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| Synonyms: | (3S,6S)-7-(2-Adamantan-1-yl-ethyl)-6-cyclohexyl-3-methyl-2,5,6,7-tetrahydro-3H-imidazo[1,2-a]imidazol-1-ium |
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| Type | Small organic molecule |
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| Emp. Form. | C24H40N3 |
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| Mol. Mass. | 370.594 |
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| SMILES | C[C@H]1C[NH+]=C2N(CCC34CC5CC(CC(C5)C3)C4)[C@H](CN12)C1CCCCC1 |r,t:3,TLB:7:8:11.10.15:13,THB:9:10:13:17.8.16,9:8:11.10.15:13,16:8:11:15.14.13,16:14:11:17.9.8| |
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| Structure | 
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