Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
---|
Ligand | BDBM50297912 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_584483 (CHEMBL1059162) |
---|
IC50 | >1000000±n/a nM |
---|
Citation | Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice. Bioorg Med Chem Lett19:4455-8 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
11-beta-hydroxysteroid dehydrogenase type 2 |
---|
Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 |
Type: | Enzyme |
Mol. Mass.: | 44141.72 |
Organism: | Homo sapiens (Human) |
Description: | Purified recombinant human 11beta-HSD2. |
Residue: | 405 |
Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
|
|
|
BDBM50297912 |
---|
n/a |
---|
Name | BDBM50297912 |
Synonyms: | 4-[(3-Chlorophenylsulfonamido)methyl]-N-(1-adamantyl)benzamide | CHEMBL559418 |
Type | Small organic molecule |
Emp. Form. | C24H27ClN2O3S |
Mol. Mass. | 459.001 |
SMILES | Clc1cccc(c1)S(=O)(=O)NCc1ccc(cc1)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:24:25:22.23.28:29,THB:24:23:29:30.25.26,26:25:22:28.27.29,26:27:22:30.24.25| |
Structure |
|