Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCell division cycle 7-related protein kinase
LigandBDBM50383739
Substrate/Competitorn/a
Meas. Tech.ChEMBL_819143 (CHEMBL2034663)
IC50 167±n/a nM
Citation Koltun, ES; Tsuhako, AL; Brown, DS; Aay, N; Arcalas, A; Chan, V; Du, H; Engst, S; Ferguson, K; Franzini, M; Galan, A; Holst, CR; Huang, P; Kane, B; Kim, MH; Li, J; Markby, D; Mohan, M; Noson, K; Plonowski, A; Richards, SJ; Robertson, S; Shaw, K; Stott, G; Stout, TJ; Young, J; Yu, P; Zaharia, CA; Zhang, W; Zhou, P; Nuss, JM; Xu, W; Kearney, PC Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett22:3727-31 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cell division cycle 7-related protein kinase
Name:Cell division cycle 7-related protein kinase
Synonyms:CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:Protein
Mol. Mass.:63908.16
Organism:Homo sapiens (Human)
Description:O00311
Residue:574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50383739
n/a
NameBDBM50383739
Synonyms:CHEMBL2030404
TypeSmall organic molecule
Emp. Form.C14H11ClFN3O2
Mol. Mass.307.707
SMILESF[C@H]1CN[C@@H](C1)c1nc2c3cc(Cl)ccc3oc2c(=O)[nH]1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: