Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM50384347 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_818177 (CHEMBL2033954) |
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IC50 | 17±n/a nM |
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Citation | Perez, HL; Banfi, P; Bertrand, J; Cai, ZW; Grebinski, JW; Kim, K; Lippy, J; Modugno, M; Naglich, J; Schmidt, RJ; Tebben, A; Vianello, P; Wei, DD; Zhang, L; Galvani, A; Lombardo, LJ; Borzilleri, RM Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists. Bioorg Med Chem Lett22:3946-50 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM50384347 |
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n/a |
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Name | BDBM50384347 |
Synonyms: | CHEMBL2031016 |
Type | Small organic molecule |
Emp. Form. | C48H48ClN5O8S |
Mol. Mass. | 890.441 |
SMILES | CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(cc1C(=O)N1CCc2ccccc2C1)C(=O)NS(=O)(=O)c1ccc2cccc(OCc3ccc(cc3)C(O)=O)c2c1 |
Structure |
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