| Reaction Details |
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 | Report a problem with these data |
| Target | Bombesin receptor subtype-3 |
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| Ligand | BDBM50381914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_857725 (CHEMBL2168752) |
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| EC50 | 130±n/a nM |
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| Citation |  Chobanian, HR; Guo, Y; Liu, P; Chioda, M; Lanza, TJ; Chang, L; Kelly, TM; Kan, Y; Palyha, O; Guan, XM; Marsh, DJ; Metzger, JM; Gorski, JN; Raustad, K; Wang, SP; Strack, AM; Miller, R; Pang, J; Madeira, M; Lyons, K; Dragovic, J; Reitman, ML; Nargund, RP; Lin, LS Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett3:252-256 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bombesin receptor subtype-3 |
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| Name: | Bombesin receptor subtype-3 |
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| Synonyms: | BRS3_MOUSE | Brs3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44239.49 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1445902 |
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| Residue: | 399 |
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| Sequence: | MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISV
GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGC
KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFAL
PEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLI
ARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYES
YANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDI
PLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
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| BDBM50381914 |
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| n/a |
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| Name | BDBM50381914 |
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| Synonyms: | CHEMBL2023109 | MK-7725 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19F6N5O5S |
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| Mol. Mass. | 615.504 |
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| SMILES | CC(C)(O)c1nc(no1)-c1cccc2Nc3nc(ccc3CN(c12)S(=O)(=O)c1ccc(OC(F)(F)F)cc1)C(F)(F)F |
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| Structure | 
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