| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-serine O-palmitoleoyltransferase porcupine |
|---|
| Ligand | BDBM50428035 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_941167 (CHEMBL2330993) |
|---|
| EC50 | 40±n/a nM |
|---|
| Citation |  Wang, X; Moon, J; Dodge, ME; Pan, X; Zhang, L; Hanson, JM; Tuladhar, R; Ma, Z; Shi, H; Williams, NS; Amatruda, JF; Carroll, TJ; Lum, L; Chen, C The development of highly potent inhibitors for porcupine. J Med Chem56:2700-4 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-serine O-palmitoleoyltransferase porcupine |
|---|
| Name: | Protein-serine O-palmitoleoyltransferase porcupine |
|---|
| Synonyms: | PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52528.36 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_941167 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
|
|
|
|---|
| BDBM50428035 |
|---|
| n/a |
|---|
| Name | BDBM50428035 |
|---|
| Synonyms: | CHEMBL2324266 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H15F3N4O2S3 |
|---|
| Mol. Mass. | 520.57 |
|---|
| SMILES | FC(F)(F)c1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
