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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ephrin type-B receptor 4 | ||
| Ligand | BDBM50428747 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_947995 (CHEMBL2344645) | ||
| IC50 | 300±n/a nM | ||
| Citation |  Lafleur, K; Dong, J; Huang, D; Caflisch, A; Nevado, C Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography. J Med Chem56:84-96 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ephrin type-B receptor 4 | |||
| Name: | Ephrin type-B receptor 4 | ||
| Synonyms: | EPHB4 | EPHB4_HUMAN | Ephrin receptor | Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor HTK). | HTK | Hepatoma transmembrane kinase | MYK1 | TYRO11 | Tyrosine-protein kinase TYRO11 | VHL/Ephrin type-B receptor 4 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 108273.51 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P54760 | ||
| Residue: | 987 | ||
| Sequence: |
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| BDBM50428747 | |||
| n/a | |||
| Name | BDBM50428747 | ||
| Synonyms: | CHEMBL2333600 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16ClN5O3 | ||
| Mol. Mass. | 421.836 | ||
| SMILES | COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1Cl |(36.42,-49.25,;36.42,-47.71,;37.75,-46.94,;39.09,-47.71,;40.42,-46.94,;40.41,-45.39,;39.08,-44.63,;37.75,-45.4,;36.42,-44.63,;36.43,-43.09,;34.96,-42.61,;34.05,-43.85,;34.95,-45.1,;34.05,-46.35,;32.58,-45.87,;31.25,-46.63,;31.25,-48.17,;29.92,-45.87,;28.59,-46.64,;29.92,-44.33,;31.25,-43.55,;31.25,-42.01,;32.58,-44.33,;37.2,-41.76,;38.74,-41.76,;39.52,-40.43,;38.75,-39.1,;37.2,-39.1,;36.43,-40.43,;34.9,-40.43,)| | ||
| Structure | 
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