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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ephrin type-B receptor 4 | ||
| Ligand | BDBM50299226 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_947994 (CHEMBL2344644) | ||
| IC50 | 4350±n/a nM | ||
| Citation |  Lafleur, K; Dong, J; Huang, D; Caflisch, A; Nevado, C Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography. J Med Chem56:84-96 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ephrin type-B receptor 4 | |||
| Name: | Ephrin type-B receptor 4 | ||
| Synonyms: | EPHB4 | EPHB4_HUMAN | Ephrin receptor | Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor HTK). | HTK | Hepatoma transmembrane kinase | MYK1 | TYRO11 | Tyrosine-protein kinase TYRO11 | VHL/Ephrin type-B receptor 4 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 108273.51 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P54760 | ||
| Residue: | 987 | ||
| Sequence: |
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| BDBM50299226 | |||
| n/a | |||
| Name | BDBM50299226 | ||
| Synonyms: | 8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1,2-f]purine-2,4(3H,8H)-dione | CHEMBL577156 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17N5O3 | ||
| Mol. Mass. | 387.3914 | ||
| SMILES | COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1 |(16.51,-2.42,;16.51,-.88,;17.85,-.11,;19.17,-.88,;20.5,-.11,;20.5,1.43,;19.17,2.19,;17.85,1.42,;16.52,2.19,;16.53,3.73,;15.06,4.22,;14.15,2.97,;15.05,1.72,;14.15,.48,;12.68,.95,;11.35,.19,;11.35,-1.35,;10.03,.96,;8.69,.18,;10.03,2.5,;11.35,3.27,;11.35,4.81,;12.68,2.5,;17.86,4.51,;19.2,3.74,;20.52,4.52,;20.52,6.06,;19.17,6.82,;17.84,6.04,)| | ||
| Structure | 
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