Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Ephrin type-B receptor 4 | ||
Ligand | BDBM50299218 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_947963 (CHEMBL2344184) | ||
IC50 | 5.0±n/a nM | ||
Citation | Lafleur, K; Dong, J; Huang, D; Caflisch, A; Nevado, C Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography. J Med Chem56:84-96 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Ephrin type-B receptor 4 | |||
Name: | Ephrin type-B receptor 4 | ||
Synonyms: | EPHB4 | EPHB4_HUMAN | Ephrin receptor | Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor HTK). | HTK | Hepatoma transmembrane kinase | MYK1 | TYRO11 | Tyrosine-protein kinase TYRO11 | VHL/Ephrin type-B receptor 4 | ||
Type: | Enzyme | ||
Mol. Mass.: | 108273.51 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P54760 | ||
Residue: | 987 | ||
Sequence: |
| ||
BDBM50299218 | |||
n/a | |||
Name | BDBM50299218 | ||
Synonyms: | 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydroxyphenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione | CHEMBL566515 | Cpd66 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H19N5O4 | ||
Mol. Mass. | 417.4174 | ||
SMILES | COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| | ||
Structure |