| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50433326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_955731 (CHEMBL2379476) |
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| IC50 | >30000±n/a nM |
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| Citation |  Stammers, TA; Coulombe, R; Rancourt, J; Thavonekham, B; Fazal, G; Goulet, S; Jakalian, A; Wernic, D; Tsantrizos, Y; Poupart, MA; Bös, M; McKercher, G; Thauvette, L; Kukolj, G; Beaulieu, PL Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg Med Chem Lett23:2585-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50433326 |
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| n/a |
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| Name | BDBM50433326 |
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| Synonyms: | CHEMBL2376562 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17NO5S |
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| Mol. Mass. | 383.418 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)Nc1cc(Oc2ccccc2)ccc1C(O)=O |
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| Structure | 
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