Reaction Details |
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Target | Methionine aminopeptidase 1 |
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Ligand | BDBM50433386 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_957175 (CHEMBL2378713) |
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EC50 | 73±n/a nM |
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Citation | Zhang, F; Bhat, S; Gabelli, SB; Chen, X; Miller, MS; Nacev, BA; Cheng, YL; Meyers, DJ; Tenney, K; Shim, JS; Crews, P; Amzel, LM; Ma, D; Liu, JO Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem56:3996-4016 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Methionine aminopeptidase 1 |
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Name: | Methionine aminopeptidase 1 |
Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
Type: | Enzyme |
Mol. Mass.: | 43220.79 |
Organism: | Homo sapiens (Human) |
Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
Residue: | 386 |
Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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BDBM50433386 |
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n/a |
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Name | BDBM50433386 |
Synonyms: | CHEMBL2375615 |
Type | Small organic molecule |
Emp. Form. | C26H26N4O |
Mol. Mass. | 410.5108 |
SMILES | CC(O)c1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1 |
Structure |
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