Reaction Details |
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Target | Sodium/glucose cotransporter 1 |
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Ligand | BDBM50448923 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1296409 (CHEMBL3130110) |
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IC50 | 3170±n/a nM |
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Citation | Xu, G; Lv, B; Roberge, JY; Xu, B; Du, J; Dong, J; Chen, Y; Peng, K; Zhang, L; Tang, X; Feng, Y; Xu, M; Fu, W; Zhang, W; Zhu, L; Deng, Z; Sheng, Z; Welihinda, A; Sun, X Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes. J Med Chem57:1236-51 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 1 |
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Name: | Sodium/glucose cotransporter 1 |
Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
Type: | Protein |
Mol. Mass.: | 73503.78 |
Organism: | Homo sapiens (Human) |
Description: | P13866 |
Residue: | 664 |
Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
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BDBM50448923 |
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n/a |
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Name | BDBM50448923 |
Synonyms: | CHEMBL3125316 | CHEMBL3125317 | CHEMBL3125318 | CHEMBL3125455 | CHEMBL3125456 | CHEMBL3125457 | CHEMBL3125458 |
Type | Small organic molecule |
Emp. Form. | C21H25ClO6 |
Mol. Mass. | 408.873 |
SMILES | CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| |
Structure |
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