Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM50007104 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1337879 (CHEMBL3240906) |
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IC50 | 6.3±n/a nM |
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Citation | Lucas, MC; Bhagirath, N; Chiao, E; Goldstein, DM; Hermann, JC; Hsu, PY; Kirchner, S; Kennedy-Smith, JJ; Kuglstatter, A; Lukacs, C; Menke, J; Niu, L; Padilla, F; Peng, Y; Polonchuk, L; Railkar, A; Slade, M; Soth, M; Xu, D; Yadava, P; Yee, C; Zhou, M; Liao, C Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors. J Med Chem57:2683-91 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM50007104 |
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n/a |
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Name | BDBM50007104 |
Synonyms: | CHEMBL3237572 | US10112928, Compound I-17 |
Type | Small organic molecule |
Emp. Form. | C20H31N7O |
Mol. Mass. | 385.5064 |
SMILES | CC(C)C[C@H](CN)Nc1cc(Nc2cccc(n2)C(C)(C)C)c(nn1)C(N)=O |r| |
Structure |
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