Reaction Details |
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Target | Amine oxidase [flavin-containing] A |
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Ligand | BDBM50072317 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1469012 (CHEMBL3412828) |
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IC50 | 1300±n/a nM |
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Citation | Beaulieu, PL; Bolger, G; Deon, D; Duplessis, M; Fazal, G; Gagnon, A; Garneau, M; LaPlante, S; Stammers, T; Kukolj, G; Duan, J Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity. Bioorg Med Chem Lett25:1140-5 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Amine oxidase [flavin-containing] A |
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Name: | Amine oxidase [flavin-containing] A |
Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) |
Type: | Protein |
Mol. Mass.: | 59689.53 |
Organism: | Homo sapiens (Human) |
Description: | P21397 |
Residue: | 527 |
Sequence: | MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
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BDBM50072317 |
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n/a |
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Name | BDBM50072317 |
Synonyms: | CHEMBL3408841 |
Type | Small organic molecule |
Emp. Form. | C34H36FN5O5 |
Mol. Mass. | 613.6785 |
SMILES | CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(F)cn4)n(C)c3c2)ccc1\C=C\C(O)=O |
Structure |
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