| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50088015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1476517 (CHEMBL3428068) |
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| IC50 | 156±n/a nM |
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| Citation |  Wan, ZY; Yao, J; Tao, Y; Mao, TQ; Wang, XL; Lu, YP; Wang, HF; Yin, H; Wu, Y; Chen, FE; De Clercq, E; Daelemans, D; Pannecouque, C Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem97:1-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
|
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|
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| BDBM50088015 |
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| n/a |
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| Name | BDBM50088015 |
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| Synonyms: | CHEMBL3426974 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27N7O4 |
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| Mol. Mass. | 501.5371 |
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| SMILES | Cc1cc(cc(C)c1Oc1ccnc(NC2CCN(CC(=O)Nc3cccc(c3)[N+]([O-])=O)CC2)n1)C#N |
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| Structure | 
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